grapefruit

[1eye]

http://www.cbc.ca/news/health/grapefrui ... -1.1253489

it includes a possibly incomplete list of medications with known grapefruit interactions.

Grapefruit juice is known to interact with some types of medications, leading to an overdose hazard.

,

Previously published reports showed that drinking a 200-mL glass of grapefruit juice once a day for three days produced a 330 per cent increase in the concentration of simvastatin, a commonly used statin, in the bloodstream compared with taking the medication with water.

and

"Taking one tablet with a glass of grapefruit juice is like taking 20 tablets with a glass of water," Bailey said. "This is unintentional overdosing. So it's not surprising that these levels go from what we call therapeutic to toxic."

It increases bioavailabiliy. Will it increase bioavailability of some good stuff too?

list:

Selected drugs that interact with grapefruit

Anti-cancer

Crizotinib.
Dasatinib.
Erlotinib.
Everolimus.
Lapatinib.
Nilotinib.
Pazopanib.
Sunitinib.
Vandetanib.
Venurafenib.

Anti-infective

Erythromycin.
Halofantrine.
Maraviroc.
Primaquine.
Quinine.
Rilpivirine.

Anti-cholesterol

Atorvastatin, (lipitor)
Lovastatin.
Simvastatin.

Cardiovascular

Amiodarone.
Apixaban.
Clopidogrel.
Dronedarone.
Eplerenone.
Felodipine.
Nifedipine.
Quinidine.
Rivaroxaban.
Ticagrelor.

Central nervous system

Alfentanil (oral).
Buspirone.
Dextromethorphan.
Fentanyl (oral).
Ketamine (oral).
Lurasidone.
Oxycodone.
Pimozide.
Quetiapine.
Triazolam.
Ziprasidone.

Gastrointestinal

Domperidone.

Immunosuppressants

Cyclosporine.
Everolimus.
Sirolimus.
Tacrolimus.

Urinary tract

Darifenacin.
Fesoterodine.
Solifenacin.
Silodosin.
Tamsulosin.