Minocycline seems to have been investigated as a possible therapy for MS and other neuological diseases for ages. In May 2004, it showed some promising results - as an immuno-modifying treatment, and it has also been suggested that it has neuro-protective properties. It is currently being trialled with Copaxone. The following research suggests how it may work
Ian
http://c.moreover.com/click/here.pl?j566561445&w=464753
Minocycline
- flipflopper
- Family Elder
- Posts: 187
- Joined: Wed Nov 09, 2005 3:00 pm
- Contact:
More on Minocycline
Thanks Ian! The article notes:
Activation of kainate receptors sensitizes oligodendrocytes to complement attack
Minocycline attenuates nitric oxide-mediated neuronal and axonal destruction in vitro
Sharon
Given that that’s the action of minocycline in inflammation, here’s an abstract which indicates inhibiting that protein (PARP-1) protects oligodendrocytes (those myelin making cells)the team determined that the drug blocks the action of poly(ADP-ribose) polymerase-1 (PARP-1), a protein that can trigger inflammation and cell death.
Activation of kainate receptors sensitizes oligodendrocytes to complement attack
A bit more info on the neuroprotection potential afforded by minocycline.Glutamate excitotoxicity and complement attack have both been implicated separately in the generation of tissue damage in multiple sclerosis and in its animal model, experimental autoimmune encephalomyelitis.
Treatment with the antioxidant Trolox and inhibition of poly(ADP-ribose) polymerase-1, but not of caspases, protected oligodendrocytes against damage induced by complement. These findings indicate that glutamate sensitization of oligodendrocytes to complement attack may contribute to white matter damage in acute and chronic neurological disorders.
Minocycline attenuates nitric oxide-mediated neuronal and axonal destruction in vitro
Minocycline is looking real good IMO.The NO donor significantly increased neuronal death and minocycline was protective under these conditions. Furthermore NO-induced reductions in axonal length were significantly attenuated by minocycline……
in addition to anti-inflammatory properties, minocycline has direct protective effects on neurons and provides further evidence for its use in disorders of the CNS.
Sharon