Gut microbiome back under the microscope

[MSUK]

A comprehensive review article examining the role of gut bacteria and the viruses that infect them in the development and progression of MS, published in Journal of Interferon & Cytokine Research, suggests a increasing number of clinical studies are pointing to a link between the autoimmune disease multiple sclerosis (MS) and the composition of microbes in the human gut, sparking new research on the gut microbiome as a potential target for MS treatment and prevention...Read more - http://www.ms-uk.org/MSnews

[1eye]

Why don't nobody listen to me? This is about FMT, which they have no found a way to patent yet. Fecal microbiota transplantation. Lots of people with hidden and not so hidden agendas will try to kill it, by warning against adverse effects, racists will try to prevent interracial transplantation, etc, etc, etc. People will be squeamish, which will prolong MS suffering. This is about poop transplants. How are they intimately associated with numerous organ systems outside the gut? Feeble minds want to know.

Microbiota of the human body perform fundamental tasks that contribute to normal development, health, and homeostasis and are intimately associated with numerous organ systems, including the gut. Microbes begin gut inhabitance immediately following birth and promote proper gut epithelial construction and function, metabolism and nutrition, and immune system development. Inappropriate immune recognition of self-tissue can lead to autoimmune disease, including conditions such as multiple sclerosis (MS), in which the immune system recognizes and attacks central nervous system tissue. Preclinical studies have demonstrated a requirement of gut microbiota for neuroinflammatory autoimmune disease in animal models, and a growing number of clinical investigations are finding associations between MS status and the composition of the gut microbiota. In this review, we examine current undertakings into better understanding the role of gut bacteria and their phages in MS development, review associations of the gut microbiota makeup and MS, and discuss potential mechanisms by which the gut microbiota may be manipulated for therapeutic benefit.