Tropospheric ozone

[Petr75]

O3
1997 Mar
Department of Environmental Medicine, New York University Medical Center, Tuxedo, USA
Ozone-induced IL-8 expression and transcription factor binding in respiratory epithelial cells
https://pubmed.ncbi.nlm.nih.gov/9124608/

Abstract

Ozone, one of the most reactive oxidant gases to which humans are routinely exposed, induces inflammation in the lower airways. The airway epithelium is one of the first targets that inhaled ozone will encounter, but its role in airway inflammation is not well understood...

---------------------------------------------------------------------------------------

MS
2023 Feb 19
IRCSS Neuromed, Pozzilli, Italy
Genetic regulation of IL-8 influences disease presentation of multiple sclerosis
https://pubmed.ncbi.nlm.nih.gov/36803228/

Conclusion: We describe for the first time a role of SNP rs2227306 of IL-8 gene in regulating the expression and the activity of this inflammatory cytokine in MS.

[Petr75]

O3

2023 Feb 16
State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing, China
Influence of different concentrations of ozone on the alteration of mitochondrial DNA copy numbers in human peripheral blood
https://pubmed.ncbi.nlm.nih.gov/36801339/

----------------------------------

MS

2008 Jul
VA Medical Center, 800 Irving Avenue, Syracuse, NY 13210, USA
Variations in mitochondrial DNA copy numbers in MS brains
https://pubmed.ncbi.nlm.nih.gov/18566918/

[Petr75]

[Petr75]

O3

October 2021
Dow Silicones Belgium SRL, Rue Jules Bordet, Parc Industriel Zone C, Belgium
Effects of ozone on stratum corneum lipid integrity and assembly
https://www.sciencedirect.com/science/a ... 8421000748

Highlights

•Ozone oxidizes unsaturated ceramides and cholesterol.
•Ozone alters ceramides headgroup architecture.
•Ozone exposed lipids form a less ordered lamellar phase.
•The changes in composition and organization alter the membranes barrier properties.
--------------------------------------------------

MS

2023 Feb 12
Department of Neuroscience and Regenerative Medicine, Augusta University, Medical College of Georgia, Augusta, USA; Laboratory of Microbiome Immunobiology, Ludwik Hirszfeld Institute of Immunology & Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland
Ceramide is implicated in humoral peripheral and intrathecal autoimmune response in MS patients
https://pubmed.ncbi.nlm.nih.gov/36821978/

Conclusion: Patients with MS have shown altered panels of anti-Cer IgGs in the CSF and serum, which might suggest a relevant, though limited role of Cer as a target for autoimmune humoral response. Utility of antibodies against Cer subspecies as potential markers for MS activity and progression deserves further investigations.

[Petr75]

O3

2016 Jan 7
Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Ozone-induced IL-17A and neutrophilic airway inflammation is orchestrated by the caspase-1-IL-1 cascade
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703985/

--------------------------------
MS

2023 Mar 1
Department of Neurology, University Hospital Bonn, Venusberg Campus, Bonn, Germany
IL-17A Facilitates Entry of Autoreactive T-Cells and Granulocytes into the CNS During EAE
https://pubmed.ncbi.nlm.nih.gov/36857006/

---------
MS

2020 Jun 26
Neutrophils: Underestimated Players in the Pathogenesis of Multiple Sclerosis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349048/

[Petr75]

O3

December, 2022
Thelancet
Global trends in ozone concentration and attributable mortality for urban, peri-urban, and rural areas between 2000 and 2019: a modelling study
https://www.thelancet.com/journals/lanp ... 1/fulltext

...Results
We first compared population-weighted ozone and ozone-attributable mortality in URCAs worldwide between 2000 and 2019. We observed clear increasing trends in population-weighted ozone concentration in all URCAs worldwide (figure 1A; appendix p 5). Compared with all other URCAs, peri-urban areas had the greatest annual increase in population-weighted ozone concentration, which increased at an annual rate of 0·25 ppb (SE 0·03 ppb) from 47 ppb in 2000 to 52 ppb in 2019, and the greatest percent change (11%) in population-weighted ozone from 2000 to 2019 (table 1; appendix p 6). In terms of simple average ozone concentration, only hinterland areas had a decrease over the 20-year period (appendix p 23). The areas with the greatest percent change in simple average ozone concentration compared with all other URCAs from 2000 to 2019 were urban areas (5%) and hinterland areas (–5%).



-------------------------------
MS

2020 Nov 11
Clare Walton, Multiple Sclerosis International Federation, London, UK
Rising prevalence of multiple sclerosis worldwide: Insights from the Atlas of MS, third edition
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7720355/

...Findings

Highlights from the epidemiology survey are as follows:

The estimated number of people with MS worldwide has increased to 2.8 million in 2020. When applying the same methodology as in 2013, the estimate is 30% higher than in 2013. The 2020 global prevalence is 35.9 [95% CI: 35.87, 35.95] per 100,000 people.
MS prevalence has increased in every world region since 2013 (Table 1). Only 14% (11/81) of countries with data at both time points reported stable or declining prevalence.

-----------------------------
MS

2023 Feb 17
Department of Neurology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
Ongoing increase in incidence and prevalence of multiple sclerosis in south-eastern Iran: A three decade study
https://pubmed.ncbi.nlm.nih.gov/36857854/

[Petr75]

[Petr75]

O3

Published on 23 Jun 2023
annalsofglobalhealth
The Relationship between Air Pollution and Brain Cancer: A Systematic Review and Meta-Analysis
https://annalsofglobalhealth.org/articl ... /aogh.3889

Conclusion: The results showed that exposure to air pollutants, such as O3 and PM2.5 absorbance, had the highest correlation with brain tumor incidence. They also showed an absence of correlation between exposure to certain pollutants (SO2, CO, NO2, PM10, PM2.5) and brain tumor incidence.



--------------------------------------------------------------
MS

2015 Mar 4
Unit of Neurology, Multiple Sclerosis Center, Regina Elena National Cancer Institute, IFO , Rome , Italy
Concurrence of Multiple Sclerosis and Brain Tumors
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349169/

... A recent study reported that MS patients have a decreased overall cancer risk, but an increased risk for brain tumor

[Petr75]

O3 goes up

2024 Apr 9
Dissecting Drivers of Ozone Pollution during the 2022 Multicity Lockdowns in China Sheds Light on Future Control Direction
https://pubmed.ncbi.nlm.nih.gov/38592860/

2023 Sep 13
Space-Based Observations of Ozone Precursors within California Wildfire Plumes and the Impacts on Ozone-NOx-VOC Chemistry
https://pubmed.ncbi.nlm.nih.gov/37703172/


2023 August 18
Air pollution trends and exceedances: ozone and particulate matter outlook in Brazilian highly urbanized zones
https://pubmed.ncbi.nlm.nih.gov/37592139/


2023 August 17
Roles of ambient temperature and relative humidity on the relationship between fine particulate matter and gaseous pollutants in the largest industrial city of Ulsan, South Korea.
https://pubmed.ncbi.nlm.nih.gov/37584799/

2023 Aug 8
Changes in Ozone Pollution Trend Characteristics and Sensitivity in Jinan from 2015 to 2020
https://pubmed.ncbi.nlm.nih.gov/37694617/



-------------------------------------------------------------
MS goes up

2023 Aug 11
A global assessment of incidence trends of autoimmune diseases from 1990 to 2019 and predicted changes to 2040.
PMID: 37572826 https://pubmed.ncbi.nlm.nih.gov/37572826/

2023 Nov 29
Gender differences in the burden of multiple sclerosis in China from 1990 to 2019 and its 25-year projection: An analysis of the Global Burden of Diseases Study
https://pubmed.ncbi.nlm.nih.gov/38033712/

2024 Apr 8
The burden of neurological conditions in north Africa and the Middle East, 1990-2019: a systematic analysis of the Global Burden of Disease Study 2019
https://pubmed.ncbi.nlm.nih.gov/38604203/

------------------------------------------------
Starter:

Energy, transport, economy....wildfire - O3/PM2,5

2023 Dec 5
Impact of wildfire smoke on ozone concentrations using a Generalized Additive Model in Salt Lake city, Utah, USA, 2006-2022 https://pubmed.ncbi.nlm.nih.gov/38051007/

----------------
2024 Mar 4
Establishing the relationship between wildfire smoke and performance metrics on finished beef cattle in Western Rangelands
https://pubmed.ncbi.nlm.nih.gov/38496706/

[Petr75]

[Petr75]

O3

2023 Aug 13
School of Health Policy and Management, Chinese Academy of Medical Sciences & Peking Union Medical College, China
Short-term exposure to ozone and ECG abnormalities in China: A nationwide longitudinal study
https://pubmed.ncbi.nlm.nih.gov/37595468/

Ambient ozone (O3) pollution has been associated with an increased risk of cardiovascular diseases. However, few studies have addressed the effect of O3 exposure on electrocardiogram (ECG) ...

--------------------------------------------------

MS

2022, June 6
Annual Meeting of the Consortium of Multiple Sclerosis Centers
Assessing Electrocardiography Alterations in Patients With Multiple Sclerosis

...Prior studies have found that MS involves changes to cardiac rate, rhythm, and structure following autonomic dysregulation..

[Petr75]

2020 Aug
Department of Labor and Environmental Hygiene, Shenyang Medical College, China
The Impact of Air Pollution on Hospitalization for Cardiovascular and Cerebrovascular Disease in Shenyang, China
https://pubmed.ncbi.nlm.nih.gov/33083324/

Abstract

Background: The aim of this study was to investigate the overall impact of PM2.5, PM10, NO2, SO2, CO, and O3 on the admission of cardiovascular and cerebrovascular disease.


MS

2020 Oct 22
Multiple Sclerosis Clinical Care and Research Centre, Department of Neuroscience, Reproductive Science and Odontostomatology, Federico II University, Naples, Italy
The Framingham cardiovascular risk score and 5-year progression of multiple sclerosis
https://pubmed.ncbi.nlm.nih.gov/33091222/

Abstract

Background: Cardiovascular risk factors and comorbidities can affect the prognosis of multiple sclerosis (MS). The Framingham risk score is an algorithm that can estimate the 10-year risk of developing macrovascular disease.


Conclusions: Higher cardiovascular risk was associated with higher risk of relapses, disability, and DMT escalation in MS. Early identification, correction and treatment of cardiovascular comorbidities should be carefully considered within MS management.
----------------------------------------------------------------



2023 Aug 23
Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, China
Long-term exposure to ambient ozone and cardiovascular diseases: evidence from two national cohort studies in China
https://pubmed.ncbi.nlm.nih.gov/37625570/

Conclusions: Long-term exposure to MDA8 O3 may increase the incidence of CVD...

[Petr75]

HAIR ??
------------------

O3

June 2008
Atmospheric Environment
Ozone interactions with human hair: Ozone uptake rates and product formation
https://www.researchgate.net/publicatio ... _formation

-----------------------------------------------------------

MS

April 9, 2015
plosone
Trace Elements in Scalp Hair Samples from Patients with Relapsing-Remitting Multiple Sclerosis
https://journals.plos.org/plosone/artic ... ne.0122142

...MS patients showed a significantly lower hair concentration of aluminum and rubidium (median values: Al = 3.76 μg/g vs. 4.49 μg/g and Rb = 0.007 μg/g vs. 0.01 μg/g;) and higher hair concentration

[Petr75]

O3

2023 Aug 25
Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
Environmental factors and incidence of thyroid cancer in the world (1990-2019): an ecological study
https://pubmed.ncbi.nlm.nih.gov/37624503/

...The modeling results showed that particulate matter pollution and O3 pollution and household PM2.5 air pollution which originated from solid fuels are risk factors for thyroid cancer

----------------------------------------------------------

MS

November 14, 2022
medicalnewstoday.com
The connection between multiple sclerosis and thyroid condition
https://www.medicalnewstoday.com/articl ... s-the-link

..The links between MS and thyroid disorders are unclear, but studies indicate that having one condition may make developing the other more likely.

[Petr75]

O3/forests
Symptom identification for broadleaf species: Symptoms are more severe on mid-aged and older leaves than on younger leaves. Older leaves are the first to develop symptoms (age effect).. http://www.ozoneinjury.org/index.php?op ... &Itemid=35

--------------------------------------

MS
Age and gut bacteria contribute to MS disease progression https://www.eurekalert.org/pub_releases ... 111717.php
Older Age at Multiple Sclerosis Onset Is an Independent Factor of Poor Prognosis https://www.ncbi.nlm.nih.gov/pubmed/28793296
Age-related small vessel disease: a potential contributor to neurodegeneration in MS https://www.ncbi.nlm.nih.gov/pubmed/27864848
Age-associated physiological and pathological changes at the blood-brain barrier https://www.ncbi.nlm.nih.gov/pubmed/27837191
Age and disability drive cognitive impairment in multiple sclerosis across disease subtypes. https://www.ncbi.nlm.nih.gov/pubmed/27738090
[Age gene expression and coexpression progressive signatures in peripheral blood leukocytes. https://www.ncbi.nlm.nih.gov/pubmed/26362218

O3
2023 Jul 25
College of Environmental Sciences and Engineering, Carbon Neutrality and Eco-Environmental Technology Innovation Center of Qingdao, Qingdao University, China
https://pubmed.ncbi.nlm.nih.gov/37624151/

Volatile organic compounds (VOCs) emitted by plant foliage play an important role in ozone (O3) and secondary organic aerosol (SOA) formation. Their emissions can be influenced by the leaf age