A review about mechanisms in PPMS
A review about mechanisms in PPMS
Abstract
Unlike relapsing remitting multiple sclerosis, there are very few therapeutic options for patients with progressive forms of multiple sclerosis. While immune mechanisms are key participants in the pathogenesis of relapsing remitting multiple sclerosis, the mechanisms underlying the development of progressive multiple sclerosis are less well understood. Putative mechanisms behind progressive multiple sclerosis have been put forth: insufficient energy production via mitochondrial dysfunction, activated microglia, iron accumulation, oxidative stress, activated astrocytes, Wallerian degeneration, apoptosis, etc. Furthermore, repair processes such as remyelination are incomplete. Experimental therapies that strive to improve metabolism within neurons and glia, e.g., oligodendrocytes, could act to counter inadequate energy supplies and/or support remyelination. Most experimental approaches have been examined as standalone interventions; however, it is apparent that the biochemical steps being targeted are part of larger pathways, which are further intertwined with other metabolic pathways. Thus, the potential benefits of a tested intervention, or of an established therapy, e.g., ocrelizumab, could be undermined by constraints on upstream and/or downstream steps. If correct, then this argues for a more comprehensive, multifaceted approach to therapy. Here we review experimental approaches to support neuronal and glial metabolism, and/or promote remyelination, which may have potential to lessen or delay progressive multiple sclerosis.
-
- Similar Topics
- Replies
- Views
- Last post
-
-
Molecular heterogeneity of pathogenic mechanisms
by frodo » Tue May 26, 2020 4:30 am » in MS Etiology and Pathogenesis - 0 Replies
- 263 Views
-
Last post by frodo
Tue May 26, 2020 4:30 am
-
-
- 0 Replies
- 304 Views
-
Last post by frodo
Fri Jul 17, 2020 9:13 am
-
- 0 Replies
- 6341 Views
-
Last post by NHE
Sat Oct 12, 2019 3:55 am
-
- 0 Replies
- 281 Views
-
Last post by frodo
Tue Sep 22, 2020 11:21 am
-
- 0 Replies
- 231 Views
-
Last post by frodo
Sun Apr 12, 2020 11:54 pm
-
-
specific CSF biomarkers review
by frodo » Fri Oct 02, 2020 6:11 am » in MS Etiology and Pathogenesis - 0 Replies
- 275 Views
-
Last post by frodo
Fri Oct 02, 2020 6:11 am
-
-
-
A Review of Various Antioxidant Compounds
by Petr75 » Sat Sep 14, 2019 10:03 pm » in Natural Approach - 1 Replies
- 6228 Views
-
Last post by NHE
Mon Sep 16, 2019 12:41 am
-
-
- 0 Replies
- 815 Views
-
Last post by frodo
Tue Sep 24, 2019 1:23 am
-
-
2019 review: Mg for CV Health (and more)
by jimmylegs » Fri May 10, 2019 3:32 pm » in Natural Approach - 0 Replies
- 1265 Views
-
Last post by jimmylegs
Fri May 10, 2019 3:32 pm
-