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This is a dentist treating himself with IV ozone. I've used it in my veterinary practice for three years. I've treated myself exactly as he does in the video. The theory is that ozone 'energizes' the blood. The theory states that most disease is the result of poor oxygen levels. Ozone causes the 2, 3 DPG enzyme to release oxygen from hemoglobin more readily. Last night I had severe pain from an embolus in my arm. I may try the IV ozone.
ozone
Re: ozone
Ozone is an oxidant. In some countries ozone is used to treat drinking water to help kill any microorganisms.
Re: ozone
10/2015
Ozone Therapy in Ethidium Bromide-Induced Demyelination in Rats: Possible Protective Effect
https://www.ncbi.nlm.nih.gov/pubmed/26467344
2016
Ozone: A Multifaceted Molecule with Unexpected Therapeutic Activity
https://www.ncbi.nlm.nih.gov/pubmed/26687830
12/10/2016
Cerebrovascular pattern improved by ozone autohemotherapy: an entropy-based study on multiple sclerosis patients
https://www.ncbi.nlm.nih.gov/pubmed/27734309
13/06/2017
Medical ozone promotes Nrf2 phosphorylation reducing oxidative stress and pro-inflammatory cytokines in multiple sclerosis patients
https://www.ncbi.nlm.nih.gov/pubmed/28623000
19/09/2017
Ozone Partially Decreases Axonal and Myelin Damage in an Experimental Sciatic Nerve Injury Model
https://www.ncbi.nlm.nih.gov/pubmed/28925753
Ozone Therapy in Ethidium Bromide-Induced Demyelination in Rats: Possible Protective Effect
https://www.ncbi.nlm.nih.gov/pubmed/26467344
2016
Ozone: A Multifaceted Molecule with Unexpected Therapeutic Activity
https://www.ncbi.nlm.nih.gov/pubmed/26687830
12/10/2016
Cerebrovascular pattern improved by ozone autohemotherapy: an entropy-based study on multiple sclerosis patients
https://www.ncbi.nlm.nih.gov/pubmed/27734309
13/06/2017
Medical ozone promotes Nrf2 phosphorylation reducing oxidative stress and pro-inflammatory cytokines in multiple sclerosis patients
https://www.ncbi.nlm.nih.gov/pubmed/28623000
19/09/2017
Ozone Partially Decreases Axonal and Myelin Damage in an Experimental Sciatic Nerve Injury Model
https://www.ncbi.nlm.nih.gov/pubmed/28925753
https://www.eboro.cz
Re: ozone
Because ozone can be administered by lay people, it might be worth looking into. I have an ozone generator which can produce ozone at medical grade concentrations. It can be given IV or it can be infused into the rectum. IVs are out of the average person's knowledge but an ozone enema can be done by anyone. It's been shown that ozone enters the bloodstream through the colon and hepatic portal system nearly as quickly as an IV. Medical grade generators range in price from $500 to $2500. Insurance generally does not cover ozone treatments.
Re: ozone
2022 Dec 2
Faculty of Environmental Sciences and Biochemistry, University of Castilla-La Mancha, Toledo, Spain
Ozone modified hypothalamic signaling enhancing thermogenesis in the TDP-43A315T transgenic model of Amyotrophic Lateral Sclerosis
https://pubmed.ncbi.nlm.nih.gov/36460700/
Abstract
Amyotrophic lateral sclerosis (ALS), a devastating progressive neurodegenerative disease, has no effective treatment. Recent evidence supports a strong metabolic component in ALS pathogenesis. Indeed, metabolic abnormalities in ALS correlate to disease susceptibility and progression, raising additional therapeutic targets against ALS. Ozone (O3), a natural bioactive molecule, has been shown to elicit beneficial effects to reduce metabolic disturbances and improved motor behavior in TDP-43A315T mice. However, it is fundamental to determine the mechanism through which O3 acts in ALS. To characterize the association between O3 exposure and disease-associated weight loss in ALS, we assessed the mRNA and protein expression profile of molecular pathways with a main role in the regulation of the metabolic homeostasis on the hypothalamus and the brown adipose tissue (BAT) at the disease end-stage, in TDP-43A315T mice compared to age-matched WT littermates. In addition, the impact of O3 exposure on the faecal bacterial community diversity, by Illumina sequencing, and on the neuromuscular junctions (NMJs), by confocal imaging, were analysed. Our findings suggest the effectiveness of O3 exposure to induce metabolic effects in the hypothalamus and BAT of TDP-43A315T mice and could be a new complementary non-pharmacological approach for ALS therapy.
Faculty of Environmental Sciences and Biochemistry, University of Castilla-La Mancha, Toledo, Spain
Ozone modified hypothalamic signaling enhancing thermogenesis in the TDP-43A315T transgenic model of Amyotrophic Lateral Sclerosis
https://pubmed.ncbi.nlm.nih.gov/36460700/
Abstract
Amyotrophic lateral sclerosis (ALS), a devastating progressive neurodegenerative disease, has no effective treatment. Recent evidence supports a strong metabolic component in ALS pathogenesis. Indeed, metabolic abnormalities in ALS correlate to disease susceptibility and progression, raising additional therapeutic targets against ALS. Ozone (O3), a natural bioactive molecule, has been shown to elicit beneficial effects to reduce metabolic disturbances and improved motor behavior in TDP-43A315T mice. However, it is fundamental to determine the mechanism through which O3 acts in ALS. To characterize the association between O3 exposure and disease-associated weight loss in ALS, we assessed the mRNA and protein expression profile of molecular pathways with a main role in the regulation of the metabolic homeostasis on the hypothalamus and the brown adipose tissue (BAT) at the disease end-stage, in TDP-43A315T mice compared to age-matched WT littermates. In addition, the impact of O3 exposure on the faecal bacterial community diversity, by Illumina sequencing, and on the neuromuscular junctions (NMJs), by confocal imaging, were analysed. Our findings suggest the effectiveness of O3 exposure to induce metabolic effects in the hypothalamus and BAT of TDP-43A315T mice and could be a new complementary non-pharmacological approach for ALS therapy.
https://www.eboro.cz
Re: ozone
2022 Sep 21
Division of Oral Implantology, Faculdade São Leopoldo Mandic, Campinas, SP, Brazil
Effect of ozone therapy on the modulation of inflammation and on new bone formation in critical defects of rat calvaria filled with autogenous graft
https://pubmed.ncbi.nlm.nih.gov/36150689/
Abstract
Objective: The aim of this study was to evaluate the effect of ozone therapy on new bone formation and inflammation modulation in defects of rat calvaria filled with autogenous bone.
Material and methods: Critical size defects were created in the calvaria of 24 male Wistar rats. The animals were randomly divided into four groups according to the treatment: G1: clot; G2: clot and covered with xenogenic membrane; G3: particulate autogenous bone graft; G4: autogenous bone graft and application of 3 mL O2/O3 gas mixture (10 µg/ml). The defects were filled immediately after surgery with a bilateral retroauricular application, in the region immediately above the incision. After 21 days, the animals were euthanized, and the samples were processed for morphometric evaluations designed to measure both the intensity of the inflammatory infiltrate, and the presence of new bone formation in the defect.
Results: The results showed a lower inflammation score and higher mean of newly formed bone in the region of the defect for the group associated with ozone therapy (G4). The bone formed in the region of the defect could be observed as being more lamellar and mineralized in the case of associated ozone therapy.
Division of Oral Implantology, Faculdade São Leopoldo Mandic, Campinas, SP, Brazil
Effect of ozone therapy on the modulation of inflammation and on new bone formation in critical defects of rat calvaria filled with autogenous graft
https://pubmed.ncbi.nlm.nih.gov/36150689/
Abstract
Objective: The aim of this study was to evaluate the effect of ozone therapy on new bone formation and inflammation modulation in defects of rat calvaria filled with autogenous bone.
Material and methods: Critical size defects were created in the calvaria of 24 male Wistar rats. The animals were randomly divided into four groups according to the treatment: G1: clot; G2: clot and covered with xenogenic membrane; G3: particulate autogenous bone graft; G4: autogenous bone graft and application of 3 mL O2/O3 gas mixture (10 µg/ml). The defects were filled immediately after surgery with a bilateral retroauricular application, in the region immediately above the incision. After 21 days, the animals were euthanized, and the samples were processed for morphometric evaluations designed to measure both the intensity of the inflammatory infiltrate, and the presence of new bone formation in the defect.
Results: The results showed a lower inflammation score and higher mean of newly formed bone in the region of the defect for the group associated with ozone therapy (G4). The bone formed in the region of the defect could be observed as being more lamellar and mineralized in the case of associated ozone therapy.
https://www.eboro.cz
Re: ozone
2024 Mar 26
Chemistry Center of Vila Real, University of Trás-os-Montes and Alto Douro (UTAD), Vila Real, Portugal
Impact of ozone therapy on mouse liver mitochondrial function and antioxidant system
https://pubmed.ncbi.nlm.nih.gov/38548043/
Abstract
Ozone therapy's efficacy might stem from the regulated and mild oxidative stress resulting from ozone's interactions with various biological elements. The present work aimed to characterize the hepatic mitochondrial response to ozone treatment and its relationship with the antioxidant system response. Two groups of mice were used: one control group and another injected intraperitoneally with an O3/O2 mixture (80 ml/kg) for 5 days. Mitochondrial respiration supported by different substrates was significantly inhibited, as well as complexes I and II/III, but not complex IV. The analysis of the electron transport chain complex activity showed significant inhibitions in complexes I and II/III but not in complex IV. These inhibitions can prevent mitochondrial reactive oxygen species (ROS) production. Additionally, there was a decline in glutathione content, unaccompanied by a rise in its oxidized form. The ozone-treated groups showed a significant increase in the activity of superoxide dismutase and glutathione peroxidase, while catalase and glutathione reductase experienced no significant alterations. Adenine nucleotides increased in the ozone group, but only the increase in adenosine diphosphate is significant, so the cell's energy charge is unaffected. This study shows that mitochondria may play a crucial role in ozone treatment. However, it also highlights the need for further studies to understand the molecular mechanism.
Chemistry Center of Vila Real, University of Trás-os-Montes and Alto Douro (UTAD), Vila Real, Portugal
Impact of ozone therapy on mouse liver mitochondrial function and antioxidant system
https://pubmed.ncbi.nlm.nih.gov/38548043/
Abstract
Ozone therapy's efficacy might stem from the regulated and mild oxidative stress resulting from ozone's interactions with various biological elements. The present work aimed to characterize the hepatic mitochondrial response to ozone treatment and its relationship with the antioxidant system response. Two groups of mice were used: one control group and another injected intraperitoneally with an O3/O2 mixture (80 ml/kg) for 5 days. Mitochondrial respiration supported by different substrates was significantly inhibited, as well as complexes I and II/III, but not complex IV. The analysis of the electron transport chain complex activity showed significant inhibitions in complexes I and II/III but not in complex IV. These inhibitions can prevent mitochondrial reactive oxygen species (ROS) production. Additionally, there was a decline in glutathione content, unaccompanied by a rise in its oxidized form. The ozone-treated groups showed a significant increase in the activity of superoxide dismutase and glutathione peroxidase, while catalase and glutathione reductase experienced no significant alterations. Adenine nucleotides increased in the ozone group, but only the increase in adenosine diphosphate is significant, so the cell's energy charge is unaffected. This study shows that mitochondria may play a crucial role in ozone treatment. However, it also highlights the need for further studies to understand the molecular mechanism.
https://www.eboro.cz
Re: ozone
2024 May 23
Intracellular Criegee's mechanism-based synergistic ozone therapy mediated by oleogels for cancer treatment
https://pubmed.ncbi.nlm.nih.gov/38782060/
Abstract
Broad cellular components-initiated efficient chemical reactions that occur in malignant cells may contribute to exploring emerging strategies for cancer treatment. Herein, an ozonated oleogel (OG(O)) was developed to achieve cancer ozone therapy (O3-T) based on intracellular Criegee's reaction. By integrating the chemo-drug, the ozone-loaded oleogel (Dox@OG(O)) was prepared as a chemotherapeutic agent for local O3-T, associated with chemotherapy (CT)/radiotherapy (RT)/immunotherapy and wound healing. The in vitro results showed that, Dox@OG(O) could achieve high ozone loading efficiency and ensure its stability. This Oleogel-mediated O3-T could directly destroy tumor cells via intracellular Criegee's reaction occurred on cell membranes, as well as the effects of tumor microenvironment (TME) regulation by the generation of oxygen/reactive oxygen species (ROS) and depletion of glutathione (GSH). Meanwhile, under the stimulation of X-ray, an accelerated free radical's production was observed, further combined with the radio-sensitivity after TME regulation, an effective anti-tumor effect would be achieved. Further on, in vivo results demonstrated that the locally implanted Dox@OG(O) could effectively inhibit the growth of both primary and secondary tumors. Considering these results above, it will serve as inspiration for future studies investigating of O3-T, especially for postoperative skin diseases.
Intracellular Criegee's mechanism-based synergistic ozone therapy mediated by oleogels for cancer treatment
https://pubmed.ncbi.nlm.nih.gov/38782060/
Abstract
Broad cellular components-initiated efficient chemical reactions that occur in malignant cells may contribute to exploring emerging strategies for cancer treatment. Herein, an ozonated oleogel (OG(O)) was developed to achieve cancer ozone therapy (O3-T) based on intracellular Criegee's reaction. By integrating the chemo-drug, the ozone-loaded oleogel (Dox@OG(O)) was prepared as a chemotherapeutic agent for local O3-T, associated with chemotherapy (CT)/radiotherapy (RT)/immunotherapy and wound healing. The in vitro results showed that, Dox@OG(O) could achieve high ozone loading efficiency and ensure its stability. This Oleogel-mediated O3-T could directly destroy tumor cells via intracellular Criegee's reaction occurred on cell membranes, as well as the effects of tumor microenvironment (TME) regulation by the generation of oxygen/reactive oxygen species (ROS) and depletion of glutathione (GSH). Meanwhile, under the stimulation of X-ray, an accelerated free radical's production was observed, further combined with the radio-sensitivity after TME regulation, an effective anti-tumor effect would be achieved. Further on, in vivo results demonstrated that the locally implanted Dox@OG(O) could effectively inhibit the growth of both primary and secondary tumors. Considering these results above, it will serve as inspiration for future studies investigating of O3-T, especially for postoperative skin diseases.
https://www.eboro.cz
Re: ozone
2024 Aug 20
Department of Implantology Latin American Institute of Dental Research and Teaching (ILAPEO), Curitiba, PR, Brazil
Unveiling the Therapeutic Potential of Systemic Ozone on Skin Wound Repair: Clinical, Histological, and Immunohistochemical Study in Rats
https://pubmed.ncbi.nlm.nih.gov/39502273/
.... accelerated tissue repair process. IHC analysis revealed greater vascular endothelial growth factor (VEGF)
-------------------------------------------
11 January 2020
Upregulation of VEGF-A and correlation between VEGF-A and FLT-1 expressions in Iranian multiple sclerosis patients
https://link.springer.com/article/10.10 ... 19-04234-2
Department of Implantology Latin American Institute of Dental Research and Teaching (ILAPEO), Curitiba, PR, Brazil
Unveiling the Therapeutic Potential of Systemic Ozone on Skin Wound Repair: Clinical, Histological, and Immunohistochemical Study in Rats
https://pubmed.ncbi.nlm.nih.gov/39502273/
.... accelerated tissue repair process. IHC analysis revealed greater vascular endothelial growth factor (VEGF)
-------------------------------------------
11 January 2020
Upregulation of VEGF-A and correlation between VEGF-A and FLT-1 expressions in Iranian multiple sclerosis patients
https://link.springer.com/article/10.10 ... 19-04234-2
https://www.eboro.cz
Re: ozone
2025 Mar 1
Laboratory of Anesthesia and Critical Care Medicine in Colleges and Universities of Shandong Province, School of Anesthesiology, Shandong Second Medical University, Weifang, Shandong, China
OZONE THERAPY AMELIORATES LPS-INDUCED ACUTE LUNG INJURY IN MICE BY INHIBITING THE NLRP3/ASC/CASPASE-1 AXIS
https://pubmed.ncbi.nlm.nih.gov/39637244/
Laboratory of Anesthesia and Critical Care Medicine in Colleges and Universities of Shandong Province, School of Anesthesiology, Shandong Second Medical University, Weifang, Shandong, China
OZONE THERAPY AMELIORATES LPS-INDUCED ACUTE LUNG INJURY IN MICE BY INHIBITING THE NLRP3/ASC/CASPASE-1 AXIS
https://pubmed.ncbi.nlm.nih.gov/39637244/
https://www.eboro.cz
Re: ozone
2025 Jan 21
Department of Emergency Medicine, Gold Coast University Hospital, Southport, Queensland, Australia
Neurological Crisis Following Intravenous Ozone Therapy; a Case Report
https://pubmed.ncbi.nlm.nih.gov/40027218/
Abstract
Ozone therapy, often marketed as an immune-boosting alternative treatment, lacks robust evidence of efficacy and poses significant safety risks. Despite claims of therapeutic benefits, Regulatory agencies, such as the U.S. Food and Drug Administration (FDA), warn against its use due to its toxic properties and lack of proven benefits at tolerable exposure levels. This case report highlights severe neurological complications, including ischemic infarcts and persistent cognitive deficits, following intravenous ozone (O3) therapy in a previously healthy patient. A 36-year-old woman presented to the emergency department with chest pain, syncope, and generalized seizure shortly after receiving intravenous ozone therapy. Diagnostic imaging revealed multiple ischemic infarcts in the thalamus and cerebellum, consistent with an embolic event. The patient required intensive care unit (ICU) admission, and despite improved neurological function experienced lasting cognitive impairments necessitating long-term rehabilitation.
Department of Emergency Medicine, Gold Coast University Hospital, Southport, Queensland, Australia
Neurological Crisis Following Intravenous Ozone Therapy; a Case Report
https://pubmed.ncbi.nlm.nih.gov/40027218/
Abstract
Ozone therapy, often marketed as an immune-boosting alternative treatment, lacks robust evidence of efficacy and poses significant safety risks. Despite claims of therapeutic benefits, Regulatory agencies, such as the U.S. Food and Drug Administration (FDA), warn against its use due to its toxic properties and lack of proven benefits at tolerable exposure levels. This case report highlights severe neurological complications, including ischemic infarcts and persistent cognitive deficits, following intravenous ozone (O3) therapy in a previously healthy patient. A 36-year-old woman presented to the emergency department with chest pain, syncope, and generalized seizure shortly after receiving intravenous ozone therapy. Diagnostic imaging revealed multiple ischemic infarcts in the thalamus and cerebellum, consistent with an embolic event. The patient required intensive care unit (ICU) admission, and despite improved neurological function experienced lasting cognitive impairments necessitating long-term rehabilitation.
https://www.eboro.cz