Inducing Oral Tolerance?
Inducing Oral Tolerance?
Anyone have any information on these trials?
Also does anyone have any information on the drug glatiramer acetate?
or any experiences?
Also does anyone have any information on the drug glatiramer acetate?
or any experiences?
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Hi Matt-
Glatiramer acetate is the generic name for Copaxone. My husband's been daily injecting since his DX in March '07. His neurologist recommended it because her research led her to believe that men presenting with similar lesions and issues as my husband did very well on the drug.
My husband's been relapse and progression free since his first attack. You might want to check on the Copaxone board here and on other sites to read other folk's opinions/experiences. We're very happy with this medication.
Not sure about oral trials. From what I've read, oral medications might be years away.
best,
AC
Glatiramer acetate is the generic name for Copaxone. My husband's been daily injecting since his DX in March '07. His neurologist recommended it because her research led her to believe that men presenting with similar lesions and issues as my husband did very well on the drug.
My husband's been relapse and progression free since his first attack. You might want to check on the Copaxone board here and on other sites to read other folk's opinions/experiences. We're very happy with this medication.
Not sure about oral trials. From what I've read, oral medications might be years away.
best,
AC
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Matt-
Did some more research for you. Teva (Copaxone's manufacturer) has completed trials and studies with oral Copax, and the results weren't any better than placebo. (google Oral copaxone for specifics) I don't think there will be any more studies on oral GA.
That said, there is tons of research coming out quite recently regarding Copaxone and its success of slowing disease progression in RRMS and even PPMS.
http://www.thisisms.com/article102.html
My husband wasn't thrilled with needles every day, but he uses the auto-inject device, and he's tolerated this medication really well. It was a good choice for him. You can private mail me if you have more specific questions-
best,
AC
Did some more research for you. Teva (Copaxone's manufacturer) has completed trials and studies with oral Copax, and the results weren't any better than placebo. (google Oral copaxone for specifics) I don't think there will be any more studies on oral GA.
That said, there is tons of research coming out quite recently regarding Copaxone and its success of slowing disease progression in RRMS and even PPMS.
http://www.thisisms.com/article102.html
My husband wasn't thrilled with needles every day, but he uses the auto-inject device, and he's tolerated this medication really well. It was a good choice for him. You can private mail me if you have more specific questions-
best,
AC
In the 1990s there have been trials trying to induce immune tolerace by giving oral mylin but they failed due to a lack of efficiency, as far as I know.
--Frank
--Frank
Treatment: Gilenya since 01/2011, CCSVI both IJV ballooned 09/2010, Tysabri stopped after 24 Infusions and positive JCV antibody test, after LDN, ABX Wheldon Regime for 1 year.
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"some heart condition" would be a ruiner for me going into a trial. My brain is already screwed, so possibly screwing with my heart is not smart, in my opinion.syckbastid wrote:Fingolimod is in Phase III trials. My neuro asked if I was interested in joining the trial (I declined). She said the main concerns at this point for side effects was some heart condition (the 80 syllable name escapes me), and a dangerous drop in blood pressure.
gwa
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On the oral copaxone thing, maybe the support person who said it would be available within 2 years was a bit confused and meant that laquinimod, which is oral, and in a phase 3 trial co-sponsored by Teva, would be available within 2 years. Which, by the way, it won't. The 2 year phase 3 trial hasn't completed enrollment yet as far as I know. I went back and checked, Teva erased oral copaxone from the website in February 2007. They tried a bunch of times to come up with an oral formulation that worked.
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Thanks for that info Dignan, that's a shame about the oral Copax though...am used to hearing the 2 yr/5 yr/10 yr upcoming breakthroughs and always take em with a HUGE pinch of salt
Back to the injections once my baby is born, really enjoyed the break from them but my legs still not looking any better despite the rest.
Back to the injections once my baby is born, really enjoyed the break from them but my legs still not looking any better despite the rest.
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