Multiple sclerosis (MS) is primarily an autoimmune disorder of unknown origin.This review focuses iron overload and oxidative stress as surrounding cause that leads to immunomodulation in chronic MS. Iron overload has been demonstrated in MS lesions, as a feature common with other neurodegenerative disorders.
However, the recent description of chronic cerebrospinal venous insufficiency (CCSVI) associated to MS, with significant anomalies in cerebral venous outflow hemodynamics, permit to propose a parallel with chronic venous disorders (CVDs) in the mechanism of iron deposition.................
MSRC CCSVI Pages - http://www.msrc.co.uk/index.cfm?fuseact ... ageid=2944