New definition of MS from Mayo, Cleveland, and Yale

[Moom9335]

Cheer, As I said, the tree falls and no one hears.
Truth, if it does not appeal to the current powers,
is powerless. Another war to be fought.

[HarryZ]

These disease models, which we already know create cortical inflammation and atrophy in vivo, need to be given the same millions of research dollars as the immunological focus. Why the NIH continues to fund immunological studies into MS, but refuses to fund mechanistic blood flow studies (such as the ones proposed by Dr. Cooke at Stanford and Dr. Haacke--who were both denied NIH money for the first times in their careers) astounds me.
cheer

Cheer,

You know I've been following MS research for decades but it doesn't surprise me in the least that research money won't be flowing to fund mechanistic blood flow studies.

One has to understand that the MS world of medicine and research has built careers and established a well structured machine with the belief that MS is an auto-immune disease. Within this structure exists docs, organizations and drug companies all interwoven with each other. Putting it mildly, an awful lot of money has been made using this model.

So anyone or anything that comes along that may threaten this is going to get a lot of resistance and down right opposition. In just one example, I was able to see up close how the NMSS in New York fought the "intrusion" of Prokarin which worked on something similar to blood flow in fighting MS symptoms. Just look at how nasty some docs were conducting hastily developed "trials" in trying to prove CCSVI was worthless. This is what people do when they feel threatened, even in the medical world.

Hopefully over time this new theory behind MS will attract the proper funding to perform the proper research needed. But the road will be bumpy to say the least.

Harry

[marcstck]

It is unconscionable that the NIH would deny funding for bloodflow studies. The medical industrial complex is very real and very entrenched, and even though many who man it are people of good intent, the ghost in the machine folds, spindles, and mutilates…

[Quest56]

It is unconscionable that the NIH would deny funding for bloodflow studies. The medical industrial complex is very real and very entrenched, and even though many who man it are people of good intent, the ghost in the machine folds, spindles, and mutilates…

You, sir, are a poet...

[Leonard]

It's official. MS is no longer primarily an autoimmune disease of white matter. It's now an inflammatory disease of gray matter.

Press release from Mayo-
http://www.bmedreport.com/archives/31937

Research from Yale-
http://www.biomedcentral.com/content/pd ... 11-152.pdf

so, the EAE model and diagnosis will be changing, now that new, more powerful imaging technology is allowing researchers to see beyond white matter lesions, into the cortex.
Maybe they'll look at ischemic/reperfusion injury and iron deposition in gray matter next?
always hopeful,
cheer

dear all,

please don't be narrow-minded on this; this is not just an inflammation of the grey matter, it is much more...
definitely, a neuropathy of the peripheral will be part of the whole picture. see also:

http://www.discoverymedicine.com/Shaopi ... infection/
http://www.thisisms.com/forum/general-d ... 8-255.html

and very hopeful,

leo

[cheerleader]

"the ghost in the machine", indeed, Marc.
I suppose that's why I may come across a bit stridently on here (I was going to say, at times...but I'm afraid it's more like always...)

The three known and in vivo modeled mechanistic methods of cortical inflammation-
1. Refluxing oscillatory blood flow 2. Ischemic injury and reperfusion and 3. iron deposition into gray matter
are all being studied, albeit without much money.
A new bio marker for MS related to ischemia--perfusion--is being presented by Zamboni and Hubbard.
The Hubbard Foundation has been raising funds for this study, and will accept any donation, no matter the size.
Jeff and I have supported the testing of "normals".
http://hubbardfoundation.org/support_th ... ation.html

Preliminary and final results of these studies will be presented at the ISNVD conference in Orlando next February. Cooke, Haacke, Zivadinov, Dake, Hubbard, Chung and his IJVVI team from Taiwan, and many new faces will be there.
http://www.isnvd.org/

cheer

[rainer]

Interesting research. I am always glad that the dead-end of auto-immunity is being taken down a peg.

However auto-immunity being an incorrect or incomplete answer does nothing whatsoever to support CCSVI research. And it is unfortunate that people continue to perpetuate that false binary and mislead people.

[cheerleader]

rainer- I offer this thread as a memento of a kinder, gentler time--please note your comment, and mine.
(I miss Dom.)
http://www.thisisms.com/forum/general-d ... c2411.html
how many more years? Jeff's doing well, thanks for asking.
cheer

[HarryZ]

rainer- I offer this thread as a memento of a kinder, gentler time--please note your comment, and mine.
(I miss Dom.)
http://www.thisisms.com/forum/general-d ... c2411.html
how many more years? Jeff's doing well, thanks for asking.
cheer

Cheer,

In that same thread, I brought up Dr. Hinton Jonez's work in the late 40's with histamine and subsequently Prokarin which appeared in 1999. The attacks they both got from the established world of MS medicine at the time are the same which happens now. The big difference today is the communication available through the internet and thus the discussion that can happen with alternative theories.

Harry