Gut bacteria linked to Multiple Sclerosis

[MSUK]

The spark that ignites multiple sclerosis may come from within. A new study in mice points to normal intestinal bacteria as a trigger for the immune disorder.

In patients with multiple sclerosis, the body’s immune system attacks the brain, stripping away a protective sheath called myelin from nerve cells. This causes inflammation that leads to the disease. Although the exact causes of MS are not known, scientists generally agree that a genetic predisposition combines with one or more environmental triggers to set off the attack on the brain. The new study provides evidence that friendly bacteria may be one of those triggers.

Mice genetically engineered to develop multiple sclerosis–like symptoms don’t get the disease when raised without any bacteria in their guts, a research team from Germany reports online October 26 in Nature. But germ-free mice that were then colonized with intestinal bacteria quickly developed the disease, the team found. About 80 percent of mice with intestinal bacteria developed MS-like symptoms, but none of the germ-free mice did.... Read More - http://www.msrc.co.uk/index.cfm/fuseact ... ageid/3021

[Filmmaker]

this is the best article about the cause of MS, I just wonder when those reserchers will find how to kill these bacteria...

[Leonard]

Please read the last posting of 26 Oct on
http://www.thisisms.com/forum/general-d ... 8-225.html
The gut bacteria are mentioned there in the second to last paragraph as the cause of the second progressive phase.
I know it is all still a bit speculative at this point but the pieces seem to fit together so neatly..

And yes, I think it is known how these bacteria can be killed off by anti-biotics.
http://www.actrims.org/wp-content/uploa ... NAL_v2.pdf
This is from June 2010. See page 34

Or http://registration.akm.ch/einsicht.php ... N_ID=11599
See the third speech. This is from ECTRIMS/ACTRIMS Oct 2011.
Here minocycline comes into the puicture as well.
I have not seen any further details and would be very interested, if anyone can find.

[Talisker]

Something on the Microbiome
http://www.bbc.co.uk/news/magazine-15356016

[sou]

I would consider it if I were a genetically modified mouse having an autoimmune disorder. I think this is not applicable to humans, though.

Yet another "give-me-funds" rubbish "MS research".

[HarryZ]

I would consider it if I were a genetically modified mouse having an autoimmune disorder. I think this is not applicable to humans, though.

Yet another "give-me-funds" rubbish "MS research".

Have to agree with you Sou. Up to now, there hasn't been one successful treatment that worked on that poor MS mouse that ended up working on humans.

Harry

[CureOrBust]

http://www.hcplive.com/conference-cover ... lapse-risk
Pediatric MS: Association Between Gut Microbiota and Relapse Risk

...The stool assessment showed 25% of cases relapsed within an estimated 166 days from baseline. A shorter relapse time was associated with an absence of Fusobacteria, but a higher level of Firmicutes, and presence of the Archaea Euryarchaeota.

After adjusting for age and other variables, only the Fusobacteria phylum remained significant. Its absence versus presence was associated with a 76% chance of an earlier relapse...

I don't remember ever reading these names on the side of any probiotic I've seen.

[1eye]

I don't believe you will find that bacterium in any probiotic supplement. We have 1000 or more species in our guts. They are the missing pieces of the human genome. We have a symbiotic relationship with them. We depend upon them for our health. A study showed that Japanese MS patients are missing two species, and have an overabundance of one species. I believe it is this imbalance, not presence or absence of one species, that causes MS. I think MS is entirely curable using a microbiota transplant from a donor who does not have this imbalance. This has been demonstrated by a doctor in Australia. Of course he dares not pursue it, because of the huge revenue streams that could be disrupted. I think money stands in the way of a lot of progress.

It is necessary to be very careful about donor microbiota, since it is also known that one can "catch" things like obesity, and who knows what else, from a transplant. Perhaps only Olympic runners should donate. I read somewhere that a hunter-gatherer population in Australia was found to have an extra 500 species in their microbiome. Their diet is the key: they have many more kinds of fiber than we do. Does that sound familiar to Terry Wahl fans?

I believe we may be able to cure hundreds of diseases this way. Cancer? The scientific method will find many things in our guts. But I have recently lost faith in it, when I saw so-called human beings were trying to give MS to macaques (followed by euthanasia). I am ashamed to be an MS patient. Why don't they study their microbiomes? It is a race to the bottom, fueled by money.

[1eye]

This was posted earlier, but in case you missed it:
http://sullivanweb.me/audio/FourThought ... cteria.mp3

I had a pretty serious childhood disease when I was 12, that required months of antibiotics. I recovered, but between that and my bad eating habits later on, I probably had a badly messed-up microbiome.

[1eye]

Does anybody know if there is any research being done in this area? Or is it just too unpleasant to think about? After all, who wants to think about poo? Most scientists would much rather inject macaques with retroviruses. Or euthanize them. Ick, poo? Let's not sanction any poo transplants because we might get sued. And who wants to get sued, over poo? The optics would, as synesthesia would have it, stink.

So let's keep euthanizing, and frig the consequences. But look, perhaps the problem is how it's being sold. It could be fun, giving all these mice poo transplants. We might someday graduate to giving macaques poo transplants. We'd never have to risk getting sued. A whole industry could be created, with the leavings of these activities.

[PointsNorth]

@1eye

One of my doctors ( Who has MS ) is in Scotland visiting a FMT clinic. Clearly 'Poo' is the future. Some Believe that poop banks are The new 'currency'.

http://www.heraldscotland.com/news/1378 ... ff_in_NHS/

[1eye]

@1eye

One of my doctors ( Who has MS ) is in Scotland visiting a FMT clinic. Clearly 'Poo' is the future. Some Believe that poop banks are The new 'currency'.

http://www.heraldscotland.com/news/1378 ... ff_in_NHS/

I think fighting Cdiff is a good idea since it's poisoning our hospitals. FMT is a good idea but it's difficult to get unless it's in a clinical trial setting. We should be able too get one in a clinic. Dr. Tom Borody has a protocol for it and it's sort of like an HSCT immune system reset. The existing microbiome is assaulted with antibiotics. The transplanted fecal matter mostly supercedes the previous microbiome. The existing microbiome, if it persists, will contain the complement of bacteria, with its unique balance, that existed during the onset and course of the chronic disease. If it is implicated in the disease pathology, it might have a host/graft conflict.

[ElliotB]

"Some Believe that poop banks are The new 'currency'"

Or, you can try to 'fix' gut bacteria the 'old fashioned way' through a diet rich in fermented/high pre-probiotic foods as well as foods that are exceptionally high in the nutrition we really need for optimal health.


Fusobacteria? Frankly, I did not know what it is. But now that I did some research, it is likely not one that you want to have in your gut and you probably don't want to consume it.

[1eye]

The bacteria contained in our guts are not privy to infect other parts of our bodies. One never wants to directly consume large numbers of most of them. Fusobacteria are especially destructive in the mouth, as they are plaque forming.

Why wouldn't you want to have it in your gut?

[thisiswater]

So who among us takes a probiotic and what kind?