2018 study: increased plasma citrulline levels in pwMS
2018 study: increased plasma citrulline levels in pwMS
Plasma citrulline levels are increased in patients with multiple sclerosis (2018)
https://www.sciencedirect.com/science/a ... 0X18300832
Highlights
•Plasma citrulline levels are increased in patients with multiple sclerosis.
•Excess citrulline does not seem to result from breakdown of the brain MBP fraction.
•Alterations of NO metabolism in peripheral leukocytes might be related.
•No correlations were found with clinical nor radiological disease parameters.
Abstract
Background
Multiple sclerosis is an inflammatory demyelinating disorder of the central nervous system (CNS). Myelin basic protein (MBP), which is one of the main compounds of CNS myelin, appears to be hypercitrullinated in the brain of patients with MS. We hypothesized that MS is associated with an increased release of citrulline from the brain.
Methods
Twenty-five patients with MS, 25 controls without neurological disease (CwND) and 25 subjects with non-MS cerebral white matter lesions were included in this study. Groups were matched for age and gender. Clinical MS disability measures were recorded by means of Expanded Disability Status Scale (EDSS) scores and Multiple Sclerosis Severity Scores (MSSS). Citrulline was assessed in plasma obtained from an antecubital peripheral vein (PV) in all participants. Additional internal jugular vein (IJV) samples were examined in 10 patients with MS and 10 CwND. Twelve patients with MS underwent brain magnetic resonance imaging to determine total brain and T2 fluid-attenuated inversion recovery lesion volume.
Results
Median [IQR] PV citrulline levels were increased in patients with MS (50.47 [86.61] μM), as compared to CwND (33.58 [43.65] μM, P = 0.042) and subjects with non-MS cerebral white matter lesions (32.41 [28.86] μM, P = 0.006). Citrulline IJV levels and IJV/PV ratios were comparable between patients with MS and CwND. No significant correlations were found between PV citrulline levels and any of the clinical, nor radiological, disease measures.
Conclusion
PV plasma levels of citrulline are elevated in patients with MS but this does not seem to result from an augmented release from the brain. Increased plasma citrulline may be a promising new biomarker in MS but the origin and significance need to be further elucidated.
take control of your own health.
pursue optimal self care, with or without a diagnosis.
Re: 2018 study: increased plasma citrulline levels in pwMS
Presumably they are looking at the process described in this article
Argininosuccinate synthase: at the center of arginine metabolism.
https://www.ncbi.nlm.nih.gov/pubmed/21494411 (go to free full text).
It has a lot of useful diagrams that make sense once you're used to it. The problem will be the number of variables.
Regards,
Re: 2018 study: increased plasma citrulline levels in pwMS
This is yet another paper that confirms the overall picture at http://www.thisisms.com/forum/general-d ... ml#p251748
-
- Similar Topics
- Replies
- Views
- Last post
-
-
2018 study: sat fat, veggies and relapse rate
by jimmylegs » Sun May 12, 2019 12:26 pm » in Parenting Kids With MS - 0 Replies
- 2663 Views
-
Last post by jimmylegs
Sun May 12, 2019 12:26 pm
-
-
- 0 Replies
- 6333 Views
-
Last post by jimmylegs
Sun May 12, 2019 12:49 pm
-
-
Re: Higher Vitamin D Levels May Promote Myelin Integrity in PMS Study Suggests
by seeva » Sat Aug 31, 2019 1:42 am » in Natural Approach - 0 Replies
- 6193 Views
-
Last post by seeva
Sat Aug 31, 2019 1:42 am
-
-
-
MS signature in plasma and CSF
by frodo » Thu Oct 31, 2019 11:53 am » in MS Etiology and Pathogenesis - 1 Replies
- 796 Views
-
Last post by Petr75
Thu Nov 21, 2019 10:29 pm
-
-
- 4 Replies
- 6641 Views
-
Last post by jimmylegs
Thu Oct 17, 2019 4:42 am
-
-
2018 review: Magnesium in addiction
by jimmylegs » Sun Apr 28, 2019 9:34 am » in Mental & Spiritual Health - 2 Replies
- 1101 Views
-
Last post by jimmylegs
Mon Apr 29, 2019 5:31 am
-
-
-
Plasma exchange works in steroid-refractory MS
by frodo » Tue Nov 19, 2019 4:06 am » in MS Etiology and Pathogenesis - 2 Replies
- 670 Views
-
Last post by frodo
Fri Dec 27, 2019 12:01 pm
-
-
-
Plasma proteins: Closer to pathogenic types discrimination
by frodo » Wed Jul 31, 2019 11:36 pm » in MS Etiology and Pathogenesis - 0 Replies
- 626 Views
-
Last post by frodo
Wed Jul 31, 2019 11:36 pm
-
-
-
nutrition for PwMS (Paralympians with MS)
by jimmylegs » Sat Mar 09, 2019 11:14 am » in Exercise and Physical Therapy - 1 Replies
- 1054 Views
-
Last post by Petr75
Sun Mar 10, 2019 2:56 am
-