S1PR2...does anyone know what this means?

[MSandI]

I have been on google all morning something. I read about S1PR2 and why it could mean ms was found more in women. I do not know exactly how this translates into simple terms, if anyone knows anything about this and can explain. That would be wonderful.
Thanks
Ann

[sardi]

I'll try a stab at it. For some reason the gene that makes this receptor is over-expressed in women and even more in women who have ms. This receptor is involved in regulating passage from the blood stream to the brain, so the idea is that it's allowing our immune cells to travel from blood stream to brain where it then attacks the myelin and causes inflammation.

If they find a way to suppress it, then we won't have to use the current brute force approach of suppressing our immune system entirely. We can focus on the area where it's doing damage.

I hope this helps but also take it with a grain of salt and please someone else chime in bc I'm very rusty in the science field. I did study biology at wash u a looong time ago. It was cool to see this.

[MSandI]

Thank you for your reply sardi
I also read something to do with the hippocampus and the cortex as well. I am wondering why this would be true in women? I looked for information everywhere if I could supplement with something. I cannot find any info. It is very lengthy and haed to grasp the concept of what and why this happens. If you can think of anything else, please let me know.
Ann

[cheerleader]

Hi Sandi--
I wrote about S1PR2 earlier this week on this thread---
http://www.thisisms.com/forum/general-d ... 24729.html

The researchers found that there is an over-expression of a protein in women's blood (especially in those who are frequently having relapses) which opens up the blood brain barrier via the endothelium (the lining of our blood vessels.) Important to understand that this opening, or "leakiness", of the blood brain barrier opens the vessels to more than just immune cells. Plasmic particles, such as iron, fibrin, bacteria or viruses can also gain access to brain tissue and cause inflammation. So, it's not simply about muting the immune system as an "answer" to this problem. It's more important to figure out how to heal the endothelium.

This overexpression of this particular protein is known to happen in hypoxia (or low oxygen) situations. Just like what we see in slowed cerebral blood flow to the brain in MS. It also happens in obesity. There are ways to repair the endothelium and blood vessels, via lifestyle measures like exercise and nutrition and venoplasty for CCSVI. I've been exploring the connection of MS to the vasculature and the endothelium for about seven years now.
Here's my blog post on S1PR2 http://ccsviinms.blogspot.com/2014/05/w ... s1pr2.html

hope it helps explain the connection!
cheer

[MSandI]

Thanks Cheer
That makes a bit more sense. I am trying to learn as much as I can about things I do not understand, so thank you very much. I just read everything you posted about s1pr2. A lot of it I read about on Saturday when I was searching the internet. I read a lot about vascular disease something about the hippocampus and the cortex as well.

http://rgd.mcw.edu/rgdweb/report/gene/m ... l?id=68334
This website has my full attention right now. Cheer, have you seen this one? There is a lot of info to digest.
Thank you Ann

[cheerleader]

Hi Ann--
The site you link is to a genetic study page, looking at S1PR2 in the rat genome...it won't really help us understand what's going on in humans in the MS study. I'll try to explain in simple terms--and include links.
It's important to understand WHY S1PR2 is in higher levels in the MS brain---learning how to block this receptor with an S1PR2 inhibitor may take many years. Doing something about lowering the levels through how we live our lives and our environment is something we can do today. We want to lower the amount of S1PR2, to strengthen the blood brain barrier, by making the endothelium (the lining of all of our blood vessels) stronger. http://www.eurekalert.org/pub_releases/ ... 050614.php

There are things we can change (environmental factors) and things we can't change (genetic factors) I like to look at the things we can change ourselves.

We're very fortunate, in that vascular researchers have been looking at the problem of higher levels of S1PR2 in inflammatory disease for many years. Neurology and immunology is just catching up in the study of the blood brain barrier.

In humans, S1PR2 shows up in higher than normal levels in people who are obese. Thin people do not have these high levels. What causes this to happen? Lower levels of oxygen are delivered to tissue, and this signals an increase in S1PR2 and creates inflammation. Losing weight is one way to lower the expression of S1PR2. This does NOT mean all people with MS are obese---it's just one of many environmental factors to consider. Something that can be changed is losing weight.
http://www.ncbi.nlm.nih.gov/pubmed/24212262

There are many other ways to strengthen the endothelium yourself---while we wait for researchers to figure out how to inhibit the receptors which make the endothelium more permeable. Here is the program I created for my husband, to do this--based on research by an endothelial cardiovascular specialist at Stanford University.
http://www.ccsvi.org/index.php/helping- ... ial-health

Hope this gives you more ideas on things you can do today to help yourself, while we wait for genetic interventions.
cheer

[MSandI]

Hi Cheer
I do understand now what s1pr2 is. Thank you very much. So if a person (female), is at normal weight and still has ms, then you are suggesting that the endothelial is damaged? So in my case...I will be starting aubagio on wed or thurs of this week. It will be a drug that is processed through the liver. And now my understanding of what you wrote, I have to have a good working liver for good endothelial health. How does that work in my case? How do I help my liver while taking this med? any ideas? I have to start this med, I know I do. I am out of options. Thank you for your time.
Ann

[zjac020]

sounds silly...but coffee enemas are good for detoxifying thr liver. in the gherson protocol.coffee enemas are key.

[MSandI]

Hi zjac020,
I have never heard of it. Off to internet search again. Thanks
Ann

[lyndacarol]

Before trying zjac's suggestion, you might investigate milk thistle.

sounds silly...but coffee enemas are good for detoxifying thr liver. in the gherson protocol.coffee enemas are key.

[cheerleader]

#3 on the Endothelial Health Program is liver health.
(Make sure to scroll down to the bottom of the page to get all of the suggestions, and talk to your own physician about any contraindications.)
http://www.ccsvi.org/index.php/helping- ... ial-health

3. Promote healthy liver function

Milk Thistle, an herb derived from a flowering thistle plant (sometimes sold as “Legalon”), contains an active liver-protecting agent called silymarin. This substance, which actually consists of a group of compounds called flavonolignans, helps repair liver cells damaged by toxic substances. Silymarin also helps prevent new liver cells from being destroyed by toxins, reduces inflammation, and has potent antioxidant effects. Sylmarin has been shown to protect the endothelium24. Note: alcohol and other substances known to damage the liver should be consumed only in moderation (or avoided altogether).

cheer

[MSandI]

Hi CHEER
I will ask the ms one to one nurse tomorrow about milk thistle.
Thanks
Ann

[Annesse]

Hi Ann,

Patients with MS have elevated levels of a cytokine called tumor necrosis factor. I explain why on this thread: http://www.thisisms.com/forum/general-d ... 22806.html

Following is one study on the association between tumor necrosis factor (TNF) and SIPR2. The researchers concluded: "Collectively, our data suggest that TNFα treatment activates autocrine S1P/S1P2 signaling, which subsequently activates NFκB and leads to the proinflammatory responses in endothelial cells." (Aubagio blocks NFκB).

http://www.sciencedirect.com/science/ar ... 2313000440

In my previous thread I posted information on the elevated levels of the hormone prolactin in patients with MS. Prolactin is an important regulator of the immune system. As the following study shows, prolactin increases the expression of TNF. http://www.ncbi.nlm.nih.gov/pubmed/7759566

Estrogen increases prolactin, which would clearly explain the elevated levels of S1PR2 and the gender bias in patients with MS and other autoimmune diseases.

I have a Facebook page I post current research on if you would like to check it out: http://www.facebook.com/autoimmunethecauseandthecure

[MSandI]

Hi Annesse
I am still reading everything you sent in your last post. I take swiss naturals b12... 1000mcg a day. I am not 100% sure if I am menopausal b/c I had a partial hysterectomy over 23 years ago. But I do believe I am. I am rrms and to start aubagio this week. I am also considering milk thistle. What would you recommend fo b12 dosage?
Thank
ANN

[Annesse]

Hi Ann,

I would not recommend you supplement with vitamin B12. Research shows that patients with MS are unable to properly metabolize the vitamin. Adding supplemental vitamin B12 to your bloodstream will not correct this. It may however greatly increase your risk of cancer. Cancer cells put out extra receptors to vitamin B12 because it helps them divide. Drug companies know this and are actually using supplemental vitamin B12 as the vehicle to deliver cytotoxic agents to cancer cells. Here is one study on this. http://www.ncbi.nlm.nih.gov/pubmed/18540842